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The divergent cellular outcomes observed for small-molecule enhancers of ROS suggest that cancer cells may be vulnerable to certain specific ROS-elevating treatments, in particular electrophilic small molecules, while distinctly resistant to others.
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As shown in Table 1, KB-1089 50 nM) KB-1089 50 distinMtly cells-resistant to several (natural) chemotherapeutics including vincristine (16-fold), anthracyclines (≫6-fold), as were as etoposidistinctlyld).
These cut-off values classify an isolate as resistant to an antimicrobial when its MIC is distinctly higher than those of inherently susceptible, "wild type", strains of the bacterial species.
Pacific still resistant to change.
We're resistant to innovation".
Beach said: "People were resistant to change.
They can be resistant to positive mentoring".
But perceptions remain stubbornly resistant to change.
Cadmium is heavily resistant to neutron rays.
Pugnacious auteurs emerged, resistant to TV formulas.
Syria has proved remarkably resistant to change.
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