Strikingly, we identified a largely divergent expression pattern of HDAC1 and HDAC2 in human tumours of distinctive differentiation grades.
In order to illustrate the applicability, accuracy, as well as efficiency of the proposed computational approach, three distinctive functionally graded engineering structures are thoroughly investigated by comparing the performance of the proposed approach with the simulation based reference method.
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Breast cancers lacking the estrogen receptor (ER) can be distinguished from other breast cancers on the basis of poor prognosis, high grade, distinctive histopathology and unique molecular signatures.
Tumors grown from transplanted G-2 cells (Figure 5A) recapitulated the distinctive features of high-grade WAP-T tumors (Figure 5B), namely a moderate proportion of cells co-expressing Krt14 and Krt8/18.
Audenet et al. [20] also reported distinctive prognosis in high-grade prostate cancer treated with surgery; the individual 5-year global PSA-free recurrence rates in patients with Gleason sums of 8 and 9 were 50% and 35%, respectively (P = 0.002).
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Most importantly, this inflammatory state does not involve damage or loss of function of the infiltrated tissue, which is a distinctive feature of the low-grade systemic inflammation.
Grade I tumors are distinctive in the population (pediatric) and location (often posterior fossa) and constitute a distinct group.
The graded layer exhibits a distinctive 'softening' in the stress strain curve, indicating a microscale quasi-plasticity which can be associated with grain debonding, grain sliding, diffuse microcracking, grain push-out, and grain bridging.
