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Candidate genes showing distinctive expression patterns in response to ethanol were clustered by pattern and further analyzed for related function, pathway membership and common transcription factor binding within and across clusters.
The distinctive expression patterns in turn highlight the central roles played by miRNAs in histogenesis of epithelial tissues and in key physiologies of placenta, testis, brain, and the hematopoietic system.
As a proof of principle study, we used GD to reconstruct the space-filling neurite patterns from 3D confocal images of 200 fruit fly GAL4 lines (collaborations with J. Simpson and G. Rubin laboratories) that have relatively distinctive expression patterns in the central nervous system.
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In accordance with their expression profiles in different organs, the identified miRNAs showed a distinctive expression pattern in the studied cell types.
Expression analysis of a subset of the ETS showed that most ETS (84%) displayed a distinctive expression pattern in a multi-tissue panel of a lactating cow verifying their existence in the bovine transcriptome.
Transcriptome studies have revealed distinctive expression patterns of ncRNA in different adipose depots, a dynamic change in ncRNA expression during BAT and WAT adipogenesis and functional importance of these ncRNAs in these biological processes [ 14, 18– 20].
The uniqueness of the tissue clustering using the miRNA expression profiles compared to that with the mRNA profiles appeared to be contributed by several groups of miRNAs with distinctive expression patterns, such as the ones in epithelial tissues, and those in placenta, testes, brain, and PBMC.
In addition, a subset of genes exhibited distinctive expression patterns as compared to their closest orthologs in Arabidopsis (Fig. 7).
An array of overlapping gene clusters with distinctive expression patterns provided insight into the regulatory differences in the responses to Bgt and Pst infection.
Ribonuclease protection assay (RPA) analyses revealed distinctive expression patterns for individual Lim-syn transcripts but all were detectable in the CNS.
In contrast, the differentially-regulated protein kinases exhibited distinctive expression patterns between the two cultivars (Additional file 6: Figure S3).
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