Each GMS protein resides in a distinctive compartment: Irgm1 predominantly on Golgi (Martens et al, 2004) but also on endolysosomal membranes (Zhao et al, in preparation), Irgm2 on Golgi membranes (Martens and Howard, 2006) and Irgm3 on ER membranes and unidentified globular structures (Taylor et al, 1997; Martens et al, 2004).
PaCS, characterized by 13-nm-thick cylindrical particles we identified as proteasome complexes, is a distinctive cytoplasmic compartment where both NOD1, a selective H. pylori receptor, and UPS components are co-concentrated.
In conclusion, it seems clear that PaCS, the novel intracellular structure where H. pylori products concentrate in vivo in colonized gastric epithelium as well as in vitro in human epithelial cell lines incubated with H. pylori products/virulence factors, is a distinctive cytoplasmic compartment where both NOD1, a selective H. pylori receptor, and UPS components are co-concentrated.
Intriguingly, the deposition of H3.3 into these two distinctive chromatin compartments appears to be dependent on two separate pathways.
Antibodies raised against synthetic peptides of the plasmodial SUMO orthologue PfSUMO, a 100-amino-acid protein, reacted with distinctive subcellular compartments of the parasitized erythrocyte during blood stage development.
It is opined that the present investigation in the light of our above-mentioned reports would enable comprehensive understanding as to how these important oxidative stress parameters are regulated in distinctive hepatic mitochondrial compartments in hypothyroidism, as to whether these are reversed by T3, and, if yes, as to what extent the damage is ameliorated.
The distinctive transcriptional profiles of different hematopoietic compartments (see Kee, 2011 for an overview) imply significant changes in TF binding as cells undergo lineage commitment and differentiation.
One distinctive visual cue was associated with each compartment.
Horn & Hardart Automats were distinctive for dispensing food from little metal compartments.
The spore's exceptional resistance is attributed to its distinctive morphology consisting of three concentric separate compartments: the core, cortex, and coat.
In addition, this study also revealed a distinctive functional difference of p53 in proliferating compartments versus their differentiated or quiescent counterparts upon stress.
