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Class I and class II c-di-GMP riboswitch domains do not share sequence or structural homology and employ distinct target recognition mechanisms.
Variation in number of and spacing between AT-hook motifs has been documented for a number of proteins in different organisms and is thought to be associated with distinct target recognition [ 32].
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The Drosophila hnRNP F/H Homolog Glorund Uses Two Distinct RNA-Binding Modes to Diversify Target Recognition.
All exocyclic MTases have nine highly conserved motifs and are further subdivided into six groups, namely α, β, γ, ζ, δ, and ε, which are characterized by a distinct linear order of the AdoMet binding region (FXGXG), target recognition domain (TRD), and catalytic motif (DPPY) [3], [8].
Co-expressed microRNAs were found to have related target recognition sites and to be encoded in distinct genomic locations.
Distinct from ZFN and TALEN systems, the separation of the target recognition and nuclease functions on orthogonal components offers extensive flexibility and simplicity for targeted genome manipulations.
First, in testing >1012 distinct variants for gRNA specificity in vitro, one study found that the +1 nucleotide plays a role in target recognition.
Then, a new recognition method based optimized WTSVM is developed to perform target recognition.
Although most type I and type III CRISPR systems require four or more distinct proteins to form multi-subunit surveillance complexes, the type I-C systems use just three proteins to achieve crRNA maturation and double-stranded DNA target recognition.
Bartel, D.P. MicroRNAs: target recognition and regulatory functions.
Bartel, D. P. MicroRNAs: target recognition and regulatory functions.
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