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Hierarchical clustering of tumor gene expression profiles has identified distinct subtypes of breast tumors.
Genomic studies have identified at least five distinct subtypes of breast tumors [ 1].
Recently, DNA microarray profiling has identified distinct subtypes of breast cancer.
Gene expression analysis has defined five distinct subtypes of breast cancer, with predictive and prognostic implications [ 9].
At least six distinct subtypes of breast tumors have been defined on the basis of gene expression profiling.
Global gene expression patterns have revealed distinct subtypes of breast cancer, and can predict metastasis and survival.
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It represents a distinct subtype of breast cancer found in 15 20% of invasive breast cancers diagnosed in the United States.
ER-/HER2+ tumors belong to a distinct subtype of breast cancer based on its gene expression profile [ 17].
Triple negative breast cancer (TNBC) is a distinct subtype of breast cancer burdened with a dismal prognosis due to the lack of effective therapeutic agents.
Tumours that are positive for ERBB2 are predominantly identified as a distinct subtype of breast cancer by the 'intrinsic' subtype classification [ 3- 6] and among the 'molecular apocrine' tumours [ 10].
ER-negative tumors may represent a distinct subtype of breast cancer, as revealed by the gene expression patterns of human breast tumors [ 41, 42], and MTHFR may have a more significant role in the development and progression of this tumor type than ER-positive tumors.
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