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Both works posed distinct, substantial challenges to the players.
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Consciousness may not require a distinct or substantial self of the traditional Cartesian sort, but at least some degree of perspectivally self-like organization seems essential for the existence of anything that might count as conscious experience.
While the localization of the two proteins is distinct, a substantial degree of overlap provides preliminary evidence that the interaction observed in vitro may plausibly occur in vivo in mouse skeletal muscle.
If indeed the anammoxosome is a separate compartment in which a distinct and substantial part of the proteome is localized, this would present a situation unique to bacteria.
Together these distinct responses represent substantial, physiologically relevant differences in the interpretation of the signal initiated by different TLR2 ligands.
Carcinoma-associated fibroblasts (CAFs) have distinct characteristics and substantial data support a role for CAFs in promoting tumor progression.
Even though depression and anxiety are conceptually distinct, there is substantial overlap between the two states that makes them difficult to distinguish in screening.
The recent literature from mouse systems, based on the study of lineage trace and myb-knockout mice, has accepted that many yolk sac-derived macrophages persist as a substantial distinct population in the adult [ 45].
Consequently, it is possible that the ribosomal ETS and ITS sequences, which are located near the chromosomal breakpoints, remain distinct under a substantial degree of interspecific genetic introgression, as in the case of Asimitellaria [ 20].
While many constructs are distinct yet share substantial overlap (as in the case of the frailty and depression constructs), it may be useful to ask the following questions: Are the distinctions between these two syndromes clinically relevant, and if so, why should we care if they are 'overlapping constructs'?
Another wicket then and there was the distinct likelihood of a substantial, potentially match-losing deficit.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com