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In breast cancer, down regulation in DROSHA and/or DICER was preferentially observed in distinct subgroups of breast cancer [ 38].
These triple-negative tumors can be subdivided in at least five distinct subgroups of breast carcinomas that differ in their overall gene-expression profile.
Very few studies have examined the possibility whether HER-2/ neu status can help discriminate aetiologically distinct subgroups of breast cancer cases, and none of them has identified the effect of increased BMI with HER-2/ neu positive tumours [ 3, 5, 7- 9].
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Breast carcinomas with squamous differentiation are a distinct subgroup of breast tumors with a high frequency of EGF receptor positivity [12].
Taken together these data support the existence of 6 distinct subgroups of ER + breast cancer, and advance efforts to increase the precision of therapeutic intervention in human breast cancer patients.
Hierarchical cluster analysis revealed five distinct subgroups of triple-negative breast cancers.
Differential expression of a nuclear CSPP1 isoform identified biologically and clinically distinct subgroups of basal-like breast carcinoma.
These data support the existence of 6 distinct subgroups of ER + breast cancer and suggest that knowledge of the ER + subgroup status of patient samples have the potential to guide therapy choice.
Mutational profiles reveal distinct subgroups of HNSCCs.
Robinson, G. et al. Novel mutations target distinct subgroups of medulloblastoma.
Curtis first defined the distinct subgroups of patients in a study published in Nature in 2012.
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