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Lévi (1973) later proposed to classify them as a distinct subclass of the Demospongiae [21], a rank maintained in the most authoritative recent classification "Systema Porifera: a guide to the classification of sponges" [22].
More precisely, each row represents a distinct subclass of the class Transmission pattern, which is a subclass of biotop: BiologicalProcess.
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As is the case with H4R3me2s, it is not clear whether the different distribution of the H4R3me2a modification represents different stages of differentiation and commitment of the OLPs or just marks a distinct subclass of these precursors.
However, an alternative interpretation is that BDNF induces the formation of a distinct subclass of integrin adhesions in the growth cone that are α-actinin negative.
Consistent with this hypothesis, stable phase differences among SCN neurons within organotypic slices are disrupted when intercellular communication is inhibited [3], and the capacity to oscillate in the absence of intercellular communication does not correspond to a distinct subclass of SCN neurons [40].
DPSL proteins are a phylogenetically distinct subclass of di-iron carboxylate proteins that assemble into a homo-dodecameric cage ∼10 nm in diameter and are widely distributed in phylogenetically diverse prokaryotes [9], [31].
It was also reported that activation of NFκB pathway helps in increased proliferation and resistance to apoptosis in distinct subclass of ER-negative breast cancers [ 61].
However, sporadic reports in which significant therapeutic potential was achieved [ 4- 6] suggest that a distinct subclass of patients with an infectious-associated phenotype may exist.
Clinically, the patient population harboring epidermal growth factor receptor (EGFR) mutations was found to have no overlap with the population harboring the EML4-ALK fusion gene, suggesting that EML4-ALK-positive cancer represents a distinct subclass of NSCLC.
Various studies examining gene expression profiles of breast cancer have allowed the molecular classification of clinically distinct subclasses of tumors [ 7, 8] and the identification of molecular markers associated with prognosis/clinical outcome [ 9- 11] and of predictive signatures that relate to therapeutic response [ 12, 13].
Our experiments highlight the complex role(s) of Lhx6 in the differentiation and maturation of distinct subclasses of cortical interneurons and provide insight into the formation of inhibitory cortical circuits and the pathogenesis of epilepsy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com