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Our work illuminates distinct steps in RAF activation that function to assemble the active conformation of the RAF kinase.
By regulating temporally distinct steps in the HCV life cycle, AAK1 and GAK represent "master regulators" of HCV infection and potential targets for antiviral strategies.
Biochemical data on RF3 mutants show that a surface region involving domains II and III is important for distinct steps in the action cycle of RF3.
Human neurological conditions associated with abnormal neuronal migration, together with spontaneous and engineered mouse mutants, define at least four distinct steps in cortical neuronal migration.
In addition, we have demonstrated that these compounds exhibit a potent activity against hepatitis C virus (HCV) by inhibiting two temporally distinct steps in the HCV lifecycle (i.e. viral entry and assembly).
The universe is analog with fields transforming in fields with no distinct steps in between.
Similar(15)
Maybe 10 years ago I would have said no, but I think now mounting a bid for 2024 would be a distinct step in the right direction," he said.
I just mean that growing turmoil does signify, by my lights, a distinct step in the unfolding of what you could call the world's destiny.
A parameter screening of the effect of pH in the range of 6.6 9.0 in borate buffer reveals a linear increase in zinc dissolution with proton concentration but a distinct step in the open circuit potential from the active state (around −700 mV SHE, pH 6.6 7.1) to the passive state (around −300 mV SHE, pH 7.4 9.0) indicating the formation of a closed passive layer.
Post-release reviews were moderately positive; while many felt that the episode was a distinct step in the right direction for the show, others took issues with some of the comedic aspects of the episode.
It differs from other currently available antiretrovirals in that it targets a distinct step in the viral life cycle namely, integration into the human genome.
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