The pro-apoptotic BH3-only proteins (e.g. Bim, Bid, Noxa, Puma) constitute the third sub-group of this family and are suggested to function as sentinels that integrate distinct extracellular and intracellular insults [ 2, 3].
The social network mediated model is distinct from a more general sentinel surveillance model in which citizens report about their health to a central authority using a web-interface or survey, as is being done under the Gripenet project centered on influenza [21].
Having more than one strain at a time leads to an increase in system complexity that cannot be tackled in a simulation model: Two different strains must be modelled as two distinct diseases, but usually existing sentinel data only monitors on the basis of ILI symptoms and does not differentiate by strain.
We conclude that in vivo, the BMP and activin A sentinels reveal overlapping and distinct domains of signaling, and that the −228 sentinel is more useful for activin A. To develop live signaling sentinels for the Wnt pathway, we employed the Wnt response elements from the SuperTOP-Flash construct, which uses a luciferase reporter assay with lysed cells (Veeman et al., 2003).
Dengue virus is known to have a distinct sylvatic cycle and has been detected in sentinel primate species40.
The derived δ18O isoscape enhances current understanding of what is a geologically distinct groundwater setting, whilst also potentially serving as a δ18O "sentinel" for continental Europe, with respect to both groundwater and precipitation, due to Ireland's geographic location.
Sentinel surveillance for influenza in India has shown distinct influenza peaks in India (6 – 8 ).
Also, ulcerated primaries have (a) a distinct gene profile [20]; (b) a severely immunosuppressed status of sentinel nodes [21] and (c) a different stromal response [22].
Distinct peaks were evident in August 2002, the first full month of the sentinel study, and in August 2003 and July 2004.
More than most buildings, skyscrapers acquire distinct personalities, not only because they are landmarks but also because they resemble human figures, giant sentinels, overlooking the city below.
Differences in behavior of distinct breast cancer histologies determine whether a patient receives breast conservation or aggressive surgical treatment, sentinel node or complete axillary dissection.
