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This distinct responsiveness is a crucial parameter to be evaluated aiming at the implementation of more efficient anticancer therapeutic strategies.
These results underline the distinct responsiveness of the different endometrial cell populations to the respective steroid hormones.
Response-based gene clustering and functional category enrichment also revealed groups of genes with distinct responsiveness to different Cdx genes.
In mice, CD27 expression divides NK cells into CD27high and CD27low subpopulations with distinct responsiveness and migratory capacity 40.
Through subgroup analyses of these large heterogeneous trials we have identified distinct responsiveness features, and the current generation of IBCSG trials investigates treatments tailored to populations based on these features (Table 1).
Recently, it was reported that CD27 dissected mature NK cells into two subsets, with distinct responsiveness and migratory capacity in the mouse, suggesting that the different effects of IFN- γ on CD49b+ NK and DBA+ uNK cells may be because of their distinct responses to IFN- γ-driven CX3CL1.
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Three areas of further research are needed which include; a CFA and clarification of the factor structure, longitudinal analysis to determine responsiveness and potentially an alteration to the questionnaire's format to provide three distinct response options per question.
A gain-of-function experiment indicated that multiple copies of all five regions were sufficient to provide the minimal promoter with a distinct ABA responsiveness.
Recently, we validated a standardized culture model of porcine oviduct epithelial cells (POEC) in large-scale trials, which exhibits distinct hormonal responsiveness during estrous cycle simulation (Chen et al. 2013a, b).
It contains a mixture of 9 different proteases with distinct pH responsivenesses, enzymatic properties and molecular weights.
The BAS includes three distinct subscales: reward responsiveness, drive, and fun seeking.
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