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We found that a series of protein receptors obtained a distinct response pattern to each target protein.
In agreement with in vivo observations, our study identified a distinct response pattern to MYC inhibition compared to cyclin D1-CDK4/6 inhibreast in breast cancer cells.
However, expression profiling of a larger panel of regulatory proteins of apoptosis in a cohort of HPV+ and HPV− HNSCC samples remains necessary to identify differentially expressed proteins that contribute to the distinct response pattern described here.
Although the difference may not be obvious within the physiological levels of Pyr in both models (1000 uM in Fig 3C&D), under the extreme perturbation (e.g. drug treatments or gene mutations), the enzyme-centric model clearly shows a distinct response pattern.
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Kriegeskorte, N., Formisano, E., Sorger, B. & Goebel, R. Individual faces elicit distinct response patterns in human anterior temporal cortex.
There are four distinct response patterns associated with favorable survival: (1) shrinkage in baseline lesions, without new lesions; (2) durable stable disease; (3) response after an initial increase in total tumour burden; (4) response in the presence of new lesions (Fig. 10).
On the other hand, it is already known that corticofugal feedback can influence the firing pattern in dLGN cells [12], [15] [17] and that thalamic cells in general, including those in the dLGN, exhibit two distinct response patterns, burst and tonic firing.
Distinct response patterns to the different TLR ligands were found (Fig. 3).
As shown in Figure 3 A, the six bacterial biofilms displayed distinct response patterns.
17 Four distinct response patterns were described: immediate response, durable stable disease, response after tumor burden increase, and response in the presence of new lesions.
In addition, 21 patients with EGFR-activating mutations were excluded because of the distinct response patterns and patient outcomes that have been observed among this population.
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