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The two Igf2-H19 loci are localized in different subnuclear compartments, having distinct replication timing characteristics, and therefore replicated asynchronously in S-phase.
It contains a distinct replication origin on each of the DNA strands.
Metazoan mtDNA contains a distinct replication origin on each of the DNA strands.
Based on previous reports and on the present study, we propose that FVs can use two distinct replication strategies depending on the target cell, as already suggested [28].
However, during replication the number of cells produced from one stem cell increases exponentially at an ideal rate of 2k, where k represents the number of distinct replication steps before the cell loses the ability to divide (Figure 1).
Herpes forms a distinct replication compartment within the nucleus of the infected cell.
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While the functional analysis of these distinct replication-dependent H2A isoforms is only beginning, the observation that their abundances are altered in primary tumor tissue supports the intriguing possibility that they may encode functionally distinct molecules [ 16, 17].
PCNA has previously been shown to form distinct DNA replication foci in the parasites during replicating trophozoite stage.
Others, particularly Jablonka and Lamb (2005, 2007), think that reproducers are distinct from replication, and that some epigenetic inheritance systems are reproducers without being replicators.
Second, the model by viral overtake meets a stumbling block: if three different viruses brought the three distinct DNA replication machineries into the three cell lineages, why have not the hallmark genes that are essential for viral DNA replication, in particular S3H and the viral-type primase, entered the genomes of any of those cellular lineages?
However, after coinfection with a MHV mutant virus lacking nsp2, the protein expressed in trans was reported to be recruited into distinct viral replication complexes.
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