Sentence examples for distinct patterns of dna from inspiring English sources

Overall, our results indicated that both Trisomy 21 and cognitive impairment were associated with distinct patterns of DNA methylation.

Unsupervised clustering clearly separated the five tissues examined here, confirming that distinct patterns of DNA methylation occur during early embryonic or fetal development.

We observed six distinct patterns of DNA methylation within our candidate gene loci in breast tumors relative to molecular subtype and matched normal tissue.

We observed distinct patterns of DNA methylation around TSSs and have uncovered several hundred novel aberrantly methylated genes in SZ and BP.

Distinct patterns of DNA methylation and histone modifications are established during cell lineage restriction to determine and maintain cell-type-specific gene expression programs.

The middle panel shows the cell cycle of wild type retinal stem cells and the putative role of the YAP/PKNOX1 complex in the control of S-phase temporal progression (represented by the distinct patterns of DNA replication foci).

Moreover, in light of this conservation, the distinct patterns of CR DNA methylation suggest that the variation in DNA methylation has a significant epigenetic component.

In gliomas, the most common human primary brain tumors, and in particular in glioblastoma, the most malignant and devastating brain tumor entity in adults, the elucidation of distinct patterns of aberrant DNA methylation, histone modification, and miRNA expression and their interrelationship has fundamentally changed our point of view on these highly heterogeneous tumors.

Infant growth restriction has been associated with distinct patterns of placental DNA methylation (Banister et al. 2011).

The study of epigenetics in colorectal cancer is relatively recent, and distinct patterns of aberrant DNA methylation, in particular the cytosine-phosphate-guanine (CpG) island methylator phenotype (CIMP), have been demonstrated in colorectal cancer, and their characterisation and significance are under debate, particularly in rectal cancer.

We observed distinct patterns of aberrant DNA methylation around transcriptional start sites (TSS) frequently occurring not in CGIs, but rather in sequences up to 2 kb distant from a CGI, termed "CpG island shores" [ 25], as well as in promoters that lack CGIs.