Wnt proteins are believed to signal through three distinct pathways, of which the canonical Wnt/β-catenin cascade is the best understood.
The potentially different origins of the tumor cells may signify distinct pathways of tumorigenesis and differences in the clinical course of the disease.
Evidence for distinct pathways of regulation is also reflected in the finding that the overexpression of these proteins is, at least in part, mediated by different transcription factors (see below).
Three distinct pathways of injury and repair characterize the podocytopathies.
"Different languages provide distinct pathways of thought and frameworks for thinking and solving problems," Harrison says.
The most likely model describing the progression from in situ to invasive breast cancer lesions is the existence of distinct pathways for the evolution of well- and poorly differentiated DCIS.
We identified distinct pathways for the development of HL60 leukemia cell resistance to apoptosis induction.
These data raises the hypothesis that mutant BRAF triggers a distinct pathway of colorectal carcinogenesis leading to the formation of MSI colorectal tumours different from the adenoma-carcinoma sequence.
40– 42 However, the distinct pathway of CD204 expression in macrophages is not completely understood.
This is consistent with skull bones possessing a distinct pathway independent of the mechano-adaptive system of the limb.
