Sentence examples for distinct mutations of the from inspiring English sources

Furthermore, red hair results from distinct mutations of the melanocortin-1 receptor.

The activity of various inhibitors of mTOR was tested on colon cancer cells that harbor distinct mutations of the catalytic subunit of PI3K (PI3KCA) [ 23, 24].

In reality, mutations of different genes will have different consequences for fitness; for example, that distinct mutations of the SETD2 gene are found in different intratumour clones in the same renal carcinoma (Gerlinger et al. 2012) indicates a strong selective pressure for inactivation of this particular gene.

Graziano et al. [ 12] reported a case of synchronous bilateral adenocarcinoma in situ of the lung with distinct mutations of EGFR gene.

45, 51 With distinct mutations of identical genes, a continuum for the multiple-organ phenotypic abnormalities was found in Meckel syndrome, Joubert syndrome/CORS, and nephronophthisis.

Finally, among the 14 Beijing isolates (both clusters), there appear to be six distinct mutations of Met306 in embB.

12– 14 More than 50 distinct mutations of BRAF gene were reported; ~90 % of them are due to a single nucleotide substitution T1799A at codon position 600 in exon 15 (p.V600E) leading to 500-fold increase in the protein activity.

Over 80 distinct mutations of EFNB1 have been reported in CFNS; these molecular lesions show a wide diversity ranging from missense substitutions to complete gene deletions, but no genotype phenotype correlation is evident.

By the introduction of molecularly targeted anti-cancer drugs, that are designed to intervene with specific pathways aberrant in cancers with distinct mutations, the type of adverse events encountered has changed greatly compared to the adverse events profile of classical chemotherapeutic agents.

This discovery highlights the existence of distinct mutations unique to the muscat-like aromatic mutants under study, as opposed to the SNP found in Muscats.

Indeed, systematic UNC-45 pull-down experiments, which were carried out at different temperatures and using cell lysates from unc-45 m94 unc-45 m94type worms reveandd that the distinct mutations affect the binding of the myosin substrate to different degrees.