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The target-centric LeMoNe approach on the other hand has the advantage to infer detailed condition-specific regulatory information through the division in distinct modules of the flagellar genes, but only infers targets for FliA and FlhC.
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The syllabus was divided into seven distinct modules on the basis of common content themes, with each module representing three to six class periods.
The Snf2-Arp7-Arp9 could even be fully detached in the absence of Snf5, highlighting the key role of Snf5 in coordinating the distinct modules of SWI/SNF (Dutta et al., 2017; Sen et al., 2017).
This is based on the unveiling of 6 distinct modules of OCT4-regulated gene regulatory networks with genes within or between each module having distinct distances between the SOX2 and OCT4 binding motifs or even not having a SOX2 motif adjacent to that of OCT4 (Fig. 6).
We have verified an enriched POU-motif, discovered by a de novo approach, thus enabling us to define six distinct modules of OCT4 binding and regulation of its target genes.
Using a range of bioinformatic analyses, distinct modules of co-expressed genes were found to be associated with specific flag leaf developmental stages.
In good agreement with this hypothesis, proteins spanning distinct modules of proteins (i.e. overlapping proteins) exhibit significant higher bridging centrality than non-overlapping proteins (one-tailed Wilcoxon test; P-Value < 2.2 10e-16).
The assumption about the pre-defined structure of the IDEEL as 3 distinct modules and the lack of data from PCA and Multi-trait analyses on the questionnaire as a whole could be raised as limitations, as the purpose of these analyses is to allow the definition of the structure and organisation of the instrument.
While DME and Clique discovered a comparable number of distinct modules, the DME modules match many more known complexes.
Fig. 6 describes the data analysis flow of PHLIP and illustrates the individual image processing functions of the 5 distinct modules constituting the program.
When we identified distinct modules, we set the threshold of minimum number of edges contained in a module as three, considering the smaller the node or edge size the lesser the distinctness.
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