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The Snf2-Arp7-Arp9 could even be fully detached in the absence of Snf5, highlighting the key role of Snf5 in coordinating the distinct modules of SWI/SNF (Dutta et al., 2017; Sen et al., 2017).
We have verified an enriched POU-motif, discovered by a de novo approach, thus enabling us to define six distinct modules of OCT4 binding and regulation of its target genes.
This is based on the unveiling of 6 distinct modules of OCT4-regulated gene regulatory networks with genes within or between each module having distinct distances between the SOX2 and OCT4 binding motifs or even not having a SOX2 motif adjacent to that of OCT4 (Fig. 6).
Using a range of bioinformatic analyses, distinct modules of co-expressed genes were found to be associated with specific flag leaf developmental stages.
In good agreement with this hypothesis, proteins spanning distinct modules of proteins (i.e. overlapping proteins) exhibit significant higher bridging centrality than non-overlapping proteins (one-tailed Wilcoxon test; P-Value < 2.2 10e-16).
The target-centric LeMoNe approach on the other hand has the advantage to infer detailed condition-specific regulatory information through the division in distinct modules of the flagellar genes, but only infers targets for FliA and FlhC.
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The syllabus was divided into seven distinct modules on the basis of common content themes, with each module representing three to six class periods.
Subsequently, this measure of gene co-expression was used in an automated hierarchical clustering procedure [ 27], resulting in the identification of several distinct modules or groups of genes with similar expression patterns.
However, when constructing gene expression networks by connecting correlated genes we observed that, even though the connections are statistically significant, extraction of distinct modules leading to biological interpretation of the network is difficult.
The assumption about the pre-defined structure of the IDEEL as 3 distinct modules and the lack of data from PCA and Multi-trait analyses on the questionnaire as a whole could be raised as limitations, as the purpose of these analyses is to allow the definition of the structure and organisation of the instrument.
Modular products are products that fulfill various functions through the combination of distinct modules.
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