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Results show that both Cd forms changed mussels' antioxidant responses with distinct modes of action (MoA).
In the present study, we investigated if gene expression profiling could be used to discriminate compound classes with distinct modes of action (MoA) using the EST protocol.
We described three major types of inhibition, and besides we identified a number of compounds (e.g., nefazodone, riluzole, flecainide) which have additional distinct modes of action.
Interestingly, the relationship between H3-K27me3 and Jmjd3 binding at its target genes points to distinct modes of action that set the stage for further investigations.
Although these differences remain rather subtle, they reinforce the notion of distinct modes of action for partial and full agonists[20].
In the multi-dimensional space defined by the eight properties of inhibition (resting and inactivated affinity, potency, reversibility, time constants of onset and offset, use-dependence and state-dependence), at least three distinct types of inhibition could be identified; these probably reflect distinct modes of action.
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Given this distinct mode of action, we asked if combined CsA and juglone therapy would be additive or synergistic.
Indeed, OBP from insect in a separate order (Lepidoptera) have a completely distinct mode of action, which has been well-documented in the literature [7], [8], [10], [12], [15], [16], [18], [19].
The synergism obtained can be explained by the distinct mode of action.
Therefore TE1 has a distinct mode of action to LatB and these accessions are useful tools to investigate the effects of this chemical in the future.
The variable in vitro cytotoxicity of NPI-0052 and Bortezomib may be owing to their distinct mode of action in MM cells including differential effects on proteasome activities.
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