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Typically, such senescence results in cells with altered morphology (large, flattened cells with high cytoplasm to nucleus ratios), telomere shortening or telomerase malfunction, distinct senescence-associated hetrochromatic foci, and increased expression of a panel of senescence-associated biomarkers (for example, senescence-associated β-galactosidase activity, INK4A, IL-6) [ 58, 60, 79].
This malfunction may be due to vulnerability of distinct neural circuits to a variety of insults leading to cellular dysfunction.
It was clearly established, by two distinct approaches (one engineering, one micromechanistic) that the stresses which produced these malfunctions were bending in nature and were the result of out-of-alignment deflections.
Wardrobe malfunctions?
Democracy malfunctions.
Malfunctions are often deadly.
"Something malfunctions in me".
Do malfunctions happen?
First the steering mechanism malfunctions.
Both batteries have had malfunctions.
And then there are more deliberate malfunctions.
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CEO of Professional Science Editing for Scientists @ prosciediting.com