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The discordant results of MHC/ageing association studies might be due to distinct linkage in different cohorts or to other interacting, genetic or environmental factors or to the heterogeneity of ageing.
SNPs genotyped in these patients show distinct linkage disequilibrium (LD) relationships in European and African descended populations [16].
Markers with more than 5 recombinants were not grouped together and are presented as distinct linkage groups for a particular chromosome.
However, considering the distinct linkage disequilibrium patterns in European and other ethnic populations, it would be of tremendous interest to determine whether such associations could be replicated in populations of other ethnicities, such as Asians.
This is likely an artifact of low diversity given that these loci have been mapped to distinct linkage groups in the related warbler A. arundinaceus (B. Hansson pers. comm).
A distinct linkage disequilibrium occurs with HLA DR or DQ alleles.
Similar(41)
The versatility arises from the ability of Ub to form polymer chains with eight distinct linkages via lysine side chains and the N terminus.
Ubiquitin has seven lysine residues (K6, K11, K27, K29, K33, K48, and K63), and can be further conjugated by another ubiquitin to form polyubiquitin chains with distinct linkages.
Moreover, due to variations in the coupling process and the distribution of basic units in plant tissue, the structural properties are dictated by the variety of chemically distinct linkages [ 5, 6].
The most distinct linkages were observed among the four S. arenicola phylotype B strains, which contained significantly more CRISPRs and spacers than strains from S. arenicola phylotypes A and ST (p < 0.05).
Another distinct amide linkage is the amino-sugar cysteine linkage seen in mycothiol, a low molecular weight reductant seen in several bacteria such as Mycobacterium [ 10].
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