The finding that tumor and normal tissue EC have distinct gene expression patterns concurs with other investigations, which describe genes that are preferentially expressed by endothelium from malignant cancer [ 12- 15].
Gene expression and functional analysis suggest that the two fish IGFBP-2 genes have undergone subfunctionalization partitioning by evolving distinct gene expression patterns, while their protein functionality remains largely unchanged.
In conclusion, acute-on-chronic and chronic human skeletal muscle ischemia result in distinct gene expression patterns.
We also highlighted some Phase II/III clinical trials using new therapeutic agents to determine clinical efficacy in novel molecular subgroups with distinct gene expression patterns.
Several studies have found distinct gene expression patterns in atherosclerotic arteries [5] [8].
A Venn diagram was generated to highlight overlapping and distinct gene expression patterns in AFCs versus AFiPSCs and ESCs.
A microarray analysis identified distinct gene expression patterns between control and tumors containing IRP2 or IRP1 transgenes.
The most common target for breast cancer metastases is bone, followed by lung, liver, and brain [10], and distinct gene expression patterns have been associated with various metastases.
Finally, we identify distinct gene expression patterns between control tumors and those overexpressing IRP2 or IRP1, that may account for their differential growth phenotypes.
Thus, while our model correctly predicts the distinct gene expression patterns embodied by the various pancreas cell types, it does not predict the fraction of each cell type in the tissue which may depend on tissue homeostasis mechanisms.
Our previous work has demonstrated that PBMCs of children with different acute infections carry distinct gene expression patterns that allow discrimination between viral and bacterial pathogens and even among subtypes of bacteria [24].
