Although more and more details about active DNA demethylation have been discovered, many questions remain to be answered, including: Which distinct functions of the three TET proteins are critical for preimplantation embryo development?
The mechanisms of HIV restriction in quiescent T cells as well as the potentially distinct functions of the two forms of A3G thus remain to be fully elucidated.
By text-mining for the alternative isoform, distinct functions of the isoforms of 9 candidate genes indicated by the result of Exon Array were confirmed.
Of the 15 genes, distinct functions of the alternative isoforms in each gene were confirmed in 9 genes, including Gnao1 (Table 3).
Similarly, Drosophila has D1, D2 and D5 receptors and we have recently identified the distinct functions of the D1 receptor dDA1 for punishment and reward memory formations in olfactory conditioning [53].
While one could hypothesize that the distinct phenotypes reported in PKBα, PKBβ, and PKBγ mutant mice are due to specific and distinct functions of the PKB isoforms, it could be equally well argued that these differences are merely due to a loss of an abundant isoform, which leads in a specific tissue to a reduction of total PKB below a critical level.
The high susceptibility of age3 mutant cells to several structurally unrelated toxic compounds, which affect distinct functions of the cell, could be caused simply by the pleiotropic consequences of disturbed vesicle traffic of several routes to different compartments of age3Δ cells.
The distinct functions of the two MAPKs may well be reproduced also in prostate cancer cells, as evidenced by our results with the inhibitors PD98059 and SB202190, thus suggesting that also in LNCaP cells p38 MAPK exerts a wider role than ERK1/2 on IL-6 and CCL5 transcription factors.
Future research will highlight distinct functions of the identified miRNAs in biomedical research deciphering cellular reorganization during juvenile intestinal development.
