Our results lend support to a DNA damage-independent function of PARP-1 sumoylation and suggest a mechanism for how the distinct functionalities of the polymerase could be delineated through its interactions with relevant forms of DNA.
As detailed in Figure S3, despite the very distinct functionalities of the different NTRs, the smFRET and FCS measurements of the different Nups and NTRs indicate similar binding characteristics as for the Nup153FG⋅Importinβ complex.
Based on these observations, we propose that the way in which PARP-1 recognises DNA may influence whether it is modified by SUMO or not, thus providing a means to delineate two distinct functionalities of the enzyme.
Integrative analyses of data on transcription factors, histone modifications, chromatin conformations and gene expression across multiple cell lines suggest distinct functionalities of these three CTCF binding sequence variations.
We have also introduced the reason for investigating the phosphorylation of three tyrosine residues with the distinct functionalities of autocatalysis, signaling and trafficking.
WiMesh consists of a core library, three libraries dedicated to distinct functionalities of WiMesh and three corresponding utilities that allow us to easily conduct experiments.
Firstly, these biopolymers can occur in multiple conformations that can have distinct functionality, with the predominant conformer depending on the molecule's environment, for instance, the presence of a particular binding partner (12 16).
Since ATM may exhibit distinct functionality because of its different localization in proliferating and differentiated SH-SY5Y cells, we compared the response of ATM to DNA damage and growth factor signaling in differentiated and undifferentiated SH-SY5Y cells.
Hence, the gene composition of the DtxR-RipA gene-regulatory network revealed the interdependence of iron metabolism and oxidative stress response and the regulatory connection between distinct physiological functionalities of the corynebacterial cell, including an important role in virulence of C. pseudotuberculosis.
