Cohesin is one of the most important cofactors of CTCF, and exhibits distinct functionalities in the presence or absence of CTCF [ 32].
Firstly, these biopolymers can occur in multiple conformations that can have distinct functionality, with the predominant conformer depending on the molecule's environment, for instance, the presence of a particular binding partner (12 16).
In general, our data correlate well with the distinct functionality of the full-length receptor tyrosine kinases and their respective intracellular domain (ICD) proteolytic fragments.
Further evidence for distinct functionality of the NCS protein family is apparent from their higher Ca2+ affinity compared to CaM, their differential cellular/tissue distributions and their non-redundancy revealed in genetic studies [23,27].
As detailed in Figure S3, despite the very distinct functionalities of the different NTRs, the smFRET and FCS measurements of the different Nups and NTRs indicate similar binding characteristics as for the Nup153FG⋅Importinβ complex.
Based on these observations, we propose that the way in which PARP-1 recognises DNA may influence whether it is modified by SUMO or not, thus providing a means to delineate two distinct functionalities of the enzyme.
Each component serves its distinct functionality and is implemented at a different stage in the biomarker discovery process.
If the different conformers have distinct functionality at a site that is distinct from the site of perturbation, allosteric behaviour is observed (12, 40, 41, 50, 51).
Paralogous HOX genes have many similarities in function but can also display distinct functionality [ 12, 13].
Since ATM may exhibit distinct functionality because of its different localization in proliferating and differentiated SH-SY5Y cells, we compared the response of ATM to DNA damage and growth factor signaling in differentiated and undifferentiated SH-SY5Y cells.
