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Our results lend support to a DNA damage-independent function of PARP-1 sumoylation and suggest a mechanism for how the distinct functionalities of the polymerase could be delineated through its interactions with relevant forms of DNA.
Based on these observations, we propose that the way in which PARP-1 recognises DNA may influence whether it is modified by SUMO or not, thus providing a means to delineate two distinct functionalities of the enzyme.
As detailed in Figure S3, despite the very distinct functionalities of the different NTRs, the smFRET and FCS measurements of the different Nups and NTRs indicate similar binding characteristics as for the Nup153FG⋅Importinβ complex.
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Integrative analyses of data on transcription factors, histone modifications, chromatin conformations and gene expression across multiple cell lines suggest distinct functionalities of these three CTCF binding sequence variations.
In general, our data correlate well with the distinct functionality of the full-length receptor tyrosine kinases and their respective intracellular domain (ICD) proteolytic fragments.
Further evidence for distinct functionality of the NCS protein family is apparent from their higher Ca2+ affinity compared to CaM, their differential cellular/tissue distributions and their non-redundancy revealed in genetic studies [23,27].
We have also introduced the reason for investigating the phosphorylation of three tyrosine residues with the distinct functionalities of autocatalysis, signaling and trafficking.
WiMesh consists of a core library, three libraries dedicated to distinct functionalities of WiMesh and three corresponding utilities that allow us to easily conduct experiments.
Hence, the gene composition of the DtxR-RipA gene-regulatory network revealed the interdependence of iron metabolism and oxidative stress response and the regulatory connection between distinct physiological functionalities of the corynebacterial cell, including an important role in virulence of C. pseudotuberculosis.
Cohesin is one of the most important cofactors of CTCF, and exhibits distinct functionalities in the presence or absence of CTCF [ 32].
A static scheduling algorithm is usually described as a monolithic process, and carries out two distinct functionalities: choosing the core to execute a specific function and evaluating the cost of the generated solutions.
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