In our model, a species was instead an a posteriori recognized entity, representing a multitude of genealogically related individuals (i.e., quasi-species [ 15]) sharing a distinct functionality in the ecosystem where they lived.
As detailed in Figure S3, despite the very distinct functionalities of the different NTRs, the smFRET and FCS measurements of the different Nups and NTRs indicate similar binding characteristics as for the Nup153FG⋅Importinβ complex.
Based on these observations, we propose that the way in which PARP-1 recognises DNA may influence whether it is modified by SUMO or not, thus providing a means to delineate two distinct functionalities of the enzyme.
Firstly, these biopolymers can occur in multiple conformations that can have distinct functionality, with the predominant conformer depending on the molecule's environment, for instance, the presence of a particular binding partner (12 16).
In general, our data correlate well with the distinct functionality of the full-length receptor tyrosine kinases and their respective intracellular domain (ICD) proteolytic fragments.
Further evidence for distinct functionality of the NCS protein family is apparent from their higher Ca2+ affinity compared to CaM, their differential cellular/tissue distributions and their non-redundancy revealed in genetic studies [23,27].
More generally, we suggest that molecules with three distinct functionalities may represent a practical upper limit on the extent of functionality present in the platform molecules that serve as the bridge between biological and chemical catalysis.
The workshop recognized the specific complexity of testicular function exemplified by dedicated cell types with distinct functionalities, as well as different cell compartments in terms of microenvironment and extracellular matrix components.
Depending on the chemical and physical properties of its microenvironment, fibronectin (also in a surface-adsorbed state) assumes different tertiary/quaternary structures [19,20], which could lead to distinct functionalities [21].
Each component serves its distinct functionality and is implemented at a different stage in the biomarker discovery process.
