In our model, a species was instead an a posteriori recognized entity, representing a multitude of genealogically related individuals (i.e., quasi-species [ 15]) sharing a distinct functionality in the ecosystem where they lived.
The workshop recognized the specific complexity of testicular function exemplified by dedicated cell types with distinct functionalities, as well as different cell compartments in terms of microenvironment and extracellular matrix components.
As detailed in Figure S3, despite the very distinct functionalities of the different NTRs, the smFRET and FCS measurements of the different Nups and NTRs indicate similar binding characteristics as for the Nup153FG⋅Importinβ complex.
We argue that zinc regulation is not only tissue-specific but also time-dependent, such that groups of genes with distinct functionalities may be regulated at different time-points following a change in zinc availability.
More generally, we suggest that molecules with three distinct functionalities may represent a practical upper limit on the extent of functionality present in the platform molecules that serve as the bridge between biological and chemical catalysis.
This model proposes that modular proteins are composed of individual folding domains that contribute distinct functionalities.
Depending on the chemical and physical properties of its microenvironment, fibronectin (also in a surface-adsorbed state) assumes different tertiary/quaternary structures [19,20], which could lead to distinct functionalities [21].
Based on these observations, we propose that the way in which PARP-1 recognises DNA may influence whether it is modified by SUMO or not, thus providing a means to delineate two distinct functionalities of the enzyme.
Paralogous HOX genes have many similarities in function but can also display distinct functionality [ 12, 13].
Since ATM may exhibit distinct functionality because of its different localization in proliferating and differentiated SH-SY5Y cells, we compared the response of ATM to DNA damage and growth factor signaling in differentiated and undifferentiated SH-SY5Y cells.
