Our results lend support to a DNA damage-independent function of PARP-1 sumoylation and suggest a mechanism for how the distinct functionalities of the polymerase could be delineated through its interactions with relevant forms of DNA.
As detailed in Figure S3, despite the very distinct functionalities of the different NTRs, the smFRET and FCS measurements of the different Nups and NTRs indicate similar binding characteristics as for the Nup153FG⋅Importinβ complex.
Further evidence for distinct functionality of the NCS protein family is apparent from their higher Ca2+ affinity compared to CaM, their differential cellular/tissue distributions and their non-redundancy revealed in genetic studies [23,27].
Firstly, these biopolymers can occur in multiple conformations that can have distinct functionality, with the predominant conformer depending on the molecule's environment, for instance, the presence of a particular binding partner (12 16).
We have also introduced the reason for investigating the phosphorylation of three tyrosine residues with the distinct functionalities of autocatalysis, signaling and trafficking.
First, we should select among the functionalities previously identified a set of interest functionalities for the target scenario.
If the different conformers have distinct functionality at a site that is distinct from the site of perturbation, allosteric behaviour is observed (12, 40, 41, 50, 51).
The fabrication of materials that require highly heterogeneous nanoscale structures, for example, where the material requires distinct functionality at different locations, is still a significant challenge.
Despite the significance of Extract Method refactoring towards code quality improvement, there is limited support for the identification of code fragments with distinct functionality that could be extracted into new methods.
Each component serves its distinct functionality and is implemented at a different stage in the biomarker discovery process.
