Sentence examples for distinct engineered from inspiring English sources

Similar observations were made in GEMM of PDA driven by distinct engineered genetic changes as the models tested before: the most striking observation was the increase collagen and CAF in the gemcitabine only treated group.

Active designer cellulosomes containing a xylanase and a cellulase were thus assembled on L. plantarum cells by co-culturing three distinct engineered strains of the bacterium: two helper strains for enzyme secretion and one producing only the anchored scaffoldin.

We then adopt a multiple-case study approach in order to validate the derivation of the new principles in the context of two, distinct engineer-to-order environments.

To further investigate the role of Hh signaling in the formation of PDA and its precursor lesion, pancreatic intraepithelial neoplasia (PanIN), we examined the effects of genetic or pharmacologic inhibition of Hh pathway activity in three distinct genetically engineered mouse models and found that Hh pathway inhibition accelerates rather than delays progression of oncogenic Kras-driven disease.

Two previous studies [22], [23] investigated the effects of ovary-specific conditional inactivation of Brca1 using distinct genetically engineered strains of mice harboring LoxP-flanked alleles of Brca1 [24], [24].

Distinct genetically engineered mice enabled her group to trace and map the origin of these cells.

Finally, we discuss TALE-based nucleases and genome regulators as distinct categories of engineered site-specific proteins that share a common DBD but differ in their effector domains, hence in their mode of action.

TALENs consist of two distinct domains, an engineered DNA-binding domain derived from the transcription activator-like effector (TALE) that provides the capability and specificity for binding target DNA sequence [ 16, 17], and a non-specific restriction endonuclease Fok I domain fused to the C-terminal of TALE that confers the nuclease activity of TALENs [ 18].

However, the ammonium side chain was replaced with the carboxylate group at pH 3. Collectively, we engineered two distinct vesicular cysteinate-Fe3+/2+ complexes, which functioned as a pH-switchable catalyst.

To explore whether ubiquitin modification of VHL leads to nuclear export and SUMO modification results in nuclear import, as well as whether ubiquitylation and SUMOylation of VHL exhibits distinct protein stability, we engineered the ubiquitin and SUMO modified VHL (VHL-UbΔGG and VHL-SUMO1ΔC4) with a mutation in lysine 171 by utilizing an artificially fused protein strategy [32].

These cellular biosensors were engineered using distinct signalling sensory modules to precisely identify various chemical signals, and combinations thereof, with a quantitative fluorescent output.