In gliomas, the most common human primary brain tumors, and in particular in glioblastoma, the most malignant and devastating brain tumor entity in adults, the elucidation of distinct patterns of aberrant DNA methylation, histone modification, and miRNA expression and their interrelationship has fundamentally changed our point of view on these highly heterogeneous tumors.
We utilized a distinct approach to the elucidation of the platelet transcriptome that, as we discovered, exhibits an extraordinary complexity.
An elucidation of the distinct mechanisms may support proposals for different remediation strategies or interventions to limit oxidative stress.
Thus, elucidation of the distinct role of T-cell subsets may lead to new insights for therapeutic interventions that regulate immune reaction following CNS injury.
The combination of several single and double digests of fractions containing multiple cyclotides and the alignment of partial sequences and assembling of peptide-specific fragments allowed the discrimination and unambiguous assignment and elucidation of the distinct cyclotide sequences.
The elucidation of a distinct outbreak pattern that is characteristic of health-care institutions suggests that a combination of host, virologic, and environmental factors mediate these divergent epidemiologic patterns.
Elucidation of a PCD mechanism distinct from metazoans in P. falciparum may yield novel drug targets to be exploited in manipulating parasite fate.
The identification of several regions of sympatry of distinct lineages offers future opportunities for the elucidation of the underlying speciation processes in the suggested species complex.
Harnessing DCs for immunotherapies in vivo requires the elucidation of the physiological role of distinct DC populations.
Furthermore, the elucidation of alternative carbon-fixation routes distinct from the Calvin cycle raises possibilities that novel pathways and organisms can be utilized to fix atmospheric carbon dioxide into useful materials.
The elucidation of the structure function relationship of distinct segments of S-layer proteins started with the production of N- and C-terminally truncated forms which were used for recrystallization and binding studies (Jarosch et al., 2001; Ilk et al., 2002; Huber et al., 2005).
