Sentence examples for distinct driver from inspiring English sources

The evaluation results on two major types of cancer (breast and lung) revealed subtypes with significant survival time difference and distinct driver mutations of individual subtypes.

Spatially separated subclones harbouring distinct driver mutations and somatic copy number aberrations (SCNAs) were present within primary tumours and between primary tumours and metastases [7 9].

In addition, the results suggested distinct driver mechanisms between mRNA and microRNA expressions and the existence of bidirectional regulatory links between microRNAs and transcription factors.

Whether this is caused by a different version of the same gene, or by a distinct driver that arose independently on S. pombe chromosome 3, will be a very interesting follow-up question.

This is a further example of how drug treatment can shape tumour biology by negatively selecting the initially dominant clone and promoting selection of a resistant clone with a distinct driver mutation.

Our prediction has resulted in 47 distinct driver genes from a total of 428 distinct candidates, as shown in Table 4 and illustrated in Figure 4. > We first analyze functional enrichment of these 47 predicted driver genes using DAVID (Huang da et al., 2009).

In this landscape, we count locally distinct drivers and barriers to a successful interaction following the logic of the triple helix model (Etzkowitz 1998; Etzkowitz and Leydesdorff et al. 2000).

Given the complex interplay of cancer and stroma that includes distinct drivers in different cancers as well as genetic and environmental differences in the patient, analysis of patterns of miRs can provide a more reliable read-out than individual miRs and will compensate for this heterogeneity.

We identified distinct driver-networks for each of the three common clinical breast cancer subtypes: oestrogen receptor (ER)+, human epidermal growth factor receptor 2 (HER2)+, and triple receptor-negative breast cancers (TNBC) from patient and cell line data sets.

We applied our novel network-based data integration method to two independent breast cancer patient data sets (Chin et al, 2006; Andre et al, 2009) and one breast cancer cell line data set (Neve et al, 2006) to identify distinct driver-networks corresponding to each subtype.

Extensive efforts have now characterized the somatic molecular alterations in human breast cancer (Cancer Genome Atlas Network, 2012; Stephens et al, 2012) and have led to a re-definition of the disease as a constellation of 10 distinct driver-based subtypes (IntClust subtypes) (Curtis et al, 2012).