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More specifically, it compares distinct dosages to attain a target strength (unconfined compressive strength and splitting tensile strength) and stiffness (initial shear modulus) using life cycle assessment (LCA).
To further test that different levels of Vangl2 phosphorylation are induced by distinct dosages of Wnt5a, cells expressing Vangl2 and Ror2 were cocultured with various numbers of Wnt5a-expressing cells.
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Diversity of drug strengths was high for both loose drugs (7 22 distinct dosage strengths per country; 37 in total) and FDCs (2 48 dosage strengths per country; 74 in total) (Table 2).
Although we cannot exclude that the tra2B background is responsible for unexpected splicing of the fru alternative transcripts, we suggest that these observations may reveal distinct dosage requirements for TRA2 in the regulation of dsx and fru splicing, respectively.
The progressive nature of Vangl2 phosphoylation suggests that different levels of Vangl2 phosphorylation is regulated by distinct Wnt5a dosages and this may be an underlying mechanism whereby responding cells interpret Wnt5a dosages.
It revealed that the rescue of the different behavioural and motor deficits showed distinct transgene dosage requirements.
Finally, it could be that an unknown regulatory mechanism, distinct from dosage compensation, also relies on DCC binding sites and/or components of the DCC in the male germline.
The work examines RNA-seq data and uses a new model (mixture of linear regression) to identify distinct classes of dosage compensation.
Moreover, the recognition that distinct molecular mechanism underlay dosage compensation in flies, worms, and humans added further support to the universality of dosage compensation evolving concomitantly with differentiated sex chromosomes (Deng et al. 2011; Straub and Becker 2011).
The treated nanocomposite relatively reduced the duration of immobility and established a distinct level in the dosage of 10 mg kg/body weight of the animals, which maintained them active.
The results (Figure 5B) showed distinct association between VLP dosage and the ability to mount a neutralizing antibody response.
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