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The normalized MLPA ratios were plotted to visualize the distinct copy numbers clusters (Figure 2).
Obviously, WCEseq profiles will be different if the different cell types have distinct copy number profiles.
Distinct copy number patterns frequently come in tandem with equally variable landscapes of somatic mutations.
In summary, our study showed genomic diversity in EOC and highlighted distinct copy number alterations in histotypes that may have potential for drug targeted therapy.
Although chromosome 3, 5 and 8 concentrated most of annotated full-length copies, Eucalyptus LTR-RTE families had distinct copy distributions, both in genic and repetitive regions.
After transforming CNV values for each SNP into deletion (CNV value < 2), normal (CNV value = 2) or amplification (CNV value > 2), distinct copy number regions were obtained by merging neighboring SNPs with identical CNVs across samples.
Similar(48)
One can say that in the first conjunct, A and B refer to books (absolutely the same book), whereas in the second conjunct, A and B refer to (absolutely distinct) copies.
Nearly all of the Elymus individuals have two distinct copies of all three genes, in clades with Pseudoroegneria and Hordeum.
This integrated analysis revealed four major subtypes defined by distinct copy-number and mutation profiles.
Sottoriva et al. [ 3] found that each individual tumour can harbour multiple distinct copy-number profiles and transcriptomic subtypes simultaneously.
For example, tumors from BRCA1- and BRCA2-mutation carriers exhibit distinct copy-number and gene-expression profiles and cluster into separate breast cancer subtypes [ 2, 18, 21], suggesting that events taking place during tumorigenesis are different and are influenced by the underlying inherited vulnerability of the key players, known as breast cancer tumor-suppressor genes.
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