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These five clusters furthermore showed specific and distinct connectivity patterns.
These findings are supported by viral tracing and electron micrograph approaches and define 2 clearly distinct connectivity endophenotypes within the autism spectrum.
Based on cyto and chemoarchitectonic features, the BNST is composed of several neuronal nuclei organized in the anterior and posterior divisions with distinct connectivity and functional implications.
We will pay special attention to the most highly connected vertices, some of which correspond to so-called certificate authorities and display a distinct connectivity pattern, which has a special meaning for trust propagation.
Resting-state fMRI (rs-fMRI) has been widely used to segregate the brain into individual modules based on the presence of distinct connectivity patterns.
The prediction tested here is that PrC and the HC show distinct connectivity with other brain regions related to performance on perceptual discrimination for such stimuli.
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In a similar manner we investigated whether enzymes belonging to different functional groups are characterized by distinct connectivities.
These hubs have high metabolic rates and are thought to be important for the integration of information processing by connecting neural processing in functionally distinct intrinsic connectivity networks (Raichle and Snyder, 2007; van den Heuvel and Sporns, 2013; Leech and Sharp, 2014).
While this assumption may be an oversimplification of the underlying network dynamics, the concept that there exist distinct functional connectivity states that recur at different points in time is compatible with computational models of neuronal connectivity (Deco et al., 2011) and observations from both fMRI (Allen et al., 2012) and EEG (Britz et al., 2010; Musso et al., 2010; Yuan et al., 2012).
Pain- and rejection-related representations are uncorrelated within regions thought to encode pain affect (for example, dorsal anterior cingulate) and show distinct functional connectivity with other regions in a separate resting-state data set (N=91).
Another aspect that needs clarification in the future is to what extent the emerging mechanisms of early network oscillations are common for limbic and sensory cortices, which at adulthood have distinct structure, connectivity and behavioural relevance (for example, five versus six layers, prominent hippocampal versus thalamic innervation)50,51.
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