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Another possible explanation is the cell types used in these studies (total PBMC vs. purified CD4+ T cells), as these are known to exhibit distinct cell specific miRNA profiles [ 65, 66].
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Here, we used our model to predict Purkinje cell spiking as well as behavior before and after learning of five different lines of mutant mice with distinct cell-specific alterations of the cerebellar cortical circuitry.
Transient transfection of various human apoAI gene plasmid constructs into human hepatoma (HepG2) and colon carcinoma (Caco-2) cells showed that apoAI gene transcription is under the control of two separate and distinct cell-specific promoters.
The results point to considerable and distinct cell-specific 5′TL heterogeneity within both the transcriptome and translatome of the two cell lines analysed.
It is possible that the two presenilins mediate distinct cell type specific functions in the CNS.
When the same stem signature gene list is analyzed using C-GSCA, the overrepresented ChIP datasets are clustered into two distinct cell type specific clusters HPC7 and MK progenitors (Fig. 4B).
These evidences strongly suggest that distinct cell type-specific light signaling pathways orchestrate gene expression in each cell type.
Hence, the presence of the two distinct cell type-specific isoforms in vertebrates creates the potential for greater functional complexity than is seen in yeast.
As such there remain many gaps in our understanding of distinct cell type-specific programs of AS that differ both between and within different tissues.
The expression of CD13 is regulated by two distinct cell type-specific promoters, the proximal or epithelial promoter and the distal or myeloid promoter.
Signaling is regulated in part by the spatial and temporal expression patterns of the different ligands and receptors, leading to distinct cell type-specific functions.
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