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They have distinct catalytic activities.
They showed quite distinct catalytic activities towards typical human P450 substrates including drugs (Figure 5).
Cell signaling proteins are often modular, containing distinct catalytic and regulatory domains.
The mutants showed distinct catalytic efficiencies with the halogenated substrate 1,2,3-trichloropropane.
Nonetheless, PLP-dependent enzymes encompass more than 140 distinct catalytic functions, thus representing a striking example of divergent evolution.
Several distinct catalytic site motifs and mechanisms have been identified among type II REases (Orlowski and Bujnicki, 2008).
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We have gone further in suggesting that multiple genes might have escaped simultaneously, or as is more likely, in concert and convergently, centered about distinct polymerase catalytic cores.
Although architecturally distinct, the catalytic triads of the bacterial and eukaryotic NHEJ polymerases are highly conserved and structurally superposable, suggesting possible convergent evolution leading to similar catalytic mechanisms.
The NOX family oxidases comprise seven members, each based on a distinct core catalytic subunit; i.e. NOX1 5 and DUOX1 2 [ 7, 66].
Nevertheless, on the basis of the partial sequence homologies (27) and structural analogy (28, 29) with PII-type ATPases, three distinct cytoplasmic catalytic domains and eight (rather than ten) transmembrane segments are defined.
CAPN8[nCL-2] and CAPN9[nCL-4] form the heterodimer CAPN8/9[G-calpain] in vivo; heterodimer formation is essential for the stable existence of CAPN8/9[G-calpain], which is the first example of a hybrid heterodimer of two distinct calpain catalytic subunits.
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