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In a recent study, he and colleague David Schnyer, also of the University of Texas, used a group of West Point cadets to try to understand how two distinct brain functions, information processing and information categorization, were affected by lack of sleep.
These conditional mutants will be valuable to investigate the role of specific groups of cholinergic neurons in distinct brain functions.
VAChTFloxNeo/del and VAChTFloxNeo/FloxNeo mice are novel complementary models to understand the specific consequences of decreased cholinergic activity in the brain and should be useful to further investigate the role of ACh in distinct brain functions.
This effect of cannabis on distinct brain functions including regulation of cortical excitability [ 17] could be the reason why cannabis consumption is associated with a higher risk of developing schizophrenia and not primarily pronounced structural brain alterations.
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99 Together with our earlier work, these data suggest that elevated orexin receptor mRNA within distinct brain sites function to create a brain-wide orexin signaling network at the level of the receptor that perpetuates heightened basal and OXA-stimulated SPA levels, which attenuates adiposity gain in OR rats.
This result might be explained by the different relevance of transmitter systems for distinct brain regions and cognitive functions.
To our knowledge, no study has been able to decompose specialised functions of distinct brain regions based simply on genes that show enrichment within that region.
Transcriptome studies have so far shown that particular subsets of neuronal genes exhibit clear spatial expression patterns across the adult mouse brain, suggesting that these spatial expression patterns are related to the unique physiological functions of distinct brain regions (Wang et al., 2010; Ko et al., 2013).
Our findings bridge the immense divide between the temporal resolutions of these distinct measures of brain function and provide strong support for the idea that the low-frequency signal fluctuations observed with R-fMRI maintain and update the intrinsic architecture underlying the brain's repertoire of functional responses.
However, deeper insights into the role of distinct HDACs in brain function will be essential for further drug development.
Given the known role of AQP4 in synaptic plasticity in the hippocampus, the widespread and region-specific expression pattern of AQP4 suggests involvement not only in fluid balance and ion homeostasis but also local synaptic plasticity and function in distinct brain circuits.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com