Indeed, it remains possible that p73 and p63 are functionally equivalent proteins, whose distinct biological functions reflect differences in expression.
First, differences in tissue- and cell type-specific expression patterns can underlie distinct biological functions, even if the proteins are functionally equivalent.
In this study, we provide the first functional evidence that the α6Bβ4 integrin can exert distinct biological functions compared to its α6Aβ4 counterpart.
In cases where transcript isoforms convey distinct biological functions, the alternatively spliced exonic regions are crucial for the between-isoform functional divergences.
Therefore, m-spinesin variants may have distinct biological functions arising from organ-specific variant expression.
The reshuffling of interchangeable molecular parts creates independent machines with similar architecture but distinct biological functions.
These complexes contain unique and shared components and have distinct biological functions in response to nutrients and growth factors (Liu et al., 2009).
In sharp contrast, genomes of microbes and viruses are incomparably more compact, with most of the genetic material assigned to distinct biological functions.
In this review, we summarize recent advantages in methods to study PTEN subcellular localization and the distinct biological functions of PTEN in different cellular compartments.
They define chromatin domains with distinct biological functions that come in sizes ranging from single modified DNA bases to several megabases in the case of heterochromatic histone modifications.
A significant number of mammalian phospholipases comprise a family of secreted PLA2 enzymes, found in specific tissues and cellular locations, exhibiting unique enzymatic properties and distinct biological functions.
