Unlike F. tularensis subsp. holarctica, the A.I. and A.II. subpopulations within F. tularensis subsp. tularensis are genetically distinct and geographically differentiated.
Genome-wide marker analyses using SNP array and diversity arrays technology (DArT) systems indicated that TauL2 was clearly distinct and genetically differentiated from TauL1 [ 18, 19].
The DR5 positive cells in the C790T LM, some of which had a high level of expression, were morphologically distinct and poorly differentiated.
Horiguchi et al., (2004) showed that neurospheres derived from different brain regions, that expressed the same region specific transcription factors, had distinct proliferation rates and differentiated into neurons specific to the region from which the progenitors were isolated [52].
Nephron tubule epithelia residents are highly specialized and differentiated, with distinct cuboidal or columnar shapes, and are polarized along their apical basal axis [ 21].
Preadipocyte metabolic and secretory profiles are distinct from differentiated fat cells and vary among fat depots (Kirkland et al., 1994, 2003; Tchkonia et al., 2007b).
In the generation of cell lines and in vitro evolution, signaling pathways which are separate and distinct in physiological differentiated cells become more and more interconnected in the derived cells (e.g., PCCl3, WRT, and FRTL5 rat thyroid cell lines) [ 41].
The view that BAT and WAT are distinct terminally differentiated tissues is supported by their different functions and morphological features [ 11] and the fact that precursor cells isolated from brown or white fat differentiate into BAs and WAs, respectively, in vitro [ 35].
Notably, ES cells transfected with Eset shRNA appeared flat and differentiated, which was clearly distinct from control ES cells, which formed compact colonies.
