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ICN not only was comparable to other well-known methods, such the random walk method (RW) and the PRINCE algorithm (PR), but also outperformed these methods when candidate disease genes are located more distantly to known disease genes in a network.
Only the surface vSAGs 41-O11, 37-K7 and 37-L15 were distantly related to known phage isolates (cyanophages and Pelagibacter phages; genome average nucleotide identity (gANI) <50%; Supplementary Fig. 9).
These sequences showed lower similarity values, being only distantly related to known taxa such as Nocardioides and Mycobacterium.
Many OTUs were only distantly related to known groups, highlighting the high diversity recovered by this approach.
Most of our problems were inherent in attempting to generate high quality alignments of short sequences that are only distantly related to known ss-rRNA genes.
Interestingly, the Arctic sample exclusively contained nifH sequences that were distantly related to known phylotypes (63 81% similarity) within Clusters III and IV.
FACIL detects alternative genetic codes even in species distantly related to known organisms.
This iterative search suggests that, contrary to our first analysis, Tn GBS transposases are distantly related to known transposase families.
Sequences of Myotis blythii and Myotis muricola browni were distantly related to known mitochondrial sequences from the genus Myotis or others from the present study.
In either case, the host lineage of the divergent environmental genes would be 439 distantly related to known organismal lineages in a way that may challenge our knowledge in evolutionary 440 microbiology.
In either case, the host lineage of the divergent environmental genes would be distantly related to known organismal lineages in a way that may challenge our knowledge of evolutionary microbiology.
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