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To successfully colonize a distant site tumor cells must overcome a series of barriers.
Allostery is the functional change at one site on a protein caused by a change at a distant site.
Most metastasis suppressors function at the translationally important stage of outgrowth of micrometastatic tumor cells at a distant site.
This metabolic biotinylation method yielded functional nanobodies with one biotin located at a distant site of the antigen-binding region of the molecule.
In essence, binding of a ligand at an allosteric site affects the function at a distant site exploiting protein flexibility and reshaping protein energy landscape.
Metastasis requires release of cells from the primary tumor, transit through the circulation or lymphatics, and extravasation at a distant site capable of sustaining their survival.
When visitors are not hosted well, don't sit near their coworkers at the distant site, and don't feel welcome, tensions can mount and site visits can go wrong.
Additionally, at a distant site, between −1378 and −1303 base-pairs, the acetylation state of H3 and H4 did not change appreciably between the undifferentiated and differentiated cells.
One can only wonder what kind of low-seeding horror show the N.C.A.A. tournament has in store for Hofstra at some distant site this time around.
Further, the 4TO7-B7-1/GPI-IL-2 and 4TO7-B7-1/GPI-IL-12 transfectants were capable of inducing regression of a wild-type tumor growing at a distant site in a concomitant tumor challenge model, suggesting the tumor immunity elicited by the transfectants can act systemically and inhibit the tumor growth at a distant site.
This project demonstrates airway management instruction for medical students using on-site instructors versus tele-mentoring by distant site instructors.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com