The use of two targets at distant position on the plasmid helps to avoid the selection of mutants with segment deletions and integration to the chromosome.
Since these two mutants have cysteine substitutions at distant positions of the protein, the apparent reduction in the binding suggests either that the epitopes of POM6 POM9 are discontinued or conformational.
The more distant positions of Yemen, grouped with African samples, and the UAE, and in a lesser degree the Qatar and Oman, proximity to Near East countries, reflect their different frequencies of African and Eurasian lineages in their respective mitochondrial pools.
Under noncontrolled (field) conditions, difficulties associated with the far-distant position of the sensors relative to the target and with the limited ability to sense only the upper soil crust currently prevent the HSR approach from being simply applied to soils.
Protein sector analysis may also provide useful information for understanding the effect of mutations at spatially distant positions on disease phenotypes.
The absence of this network motif simply indicates that close sequences of this HCV genomic region often differ at distant positions, instead of differing in states of the same position.
First, think tanks have typically maintained an ethos of nonpartisanship and scientific rationality, preferring to remain at the aloof from political battles in favor of a more distant position as neutral arbiter of policy solutions.
