Sentence examples for distant niche from inspiring English sources

The concept of the distant niche anticipating an invader and getting ready for it could be adopted as follows.

The establishment of a distant niche by stromal cells in response to paracrine tumour cell signalling appears to be an important step in metastasis formation.

Both cancer cell-derived or stromal cell-derived exosomes are thus able to alter the tumor environment and may participate in forming a distant metastatic niche to promote metastasis.

Our data show that Abd-B, through local signaling between adjucent cell types, provides positional cues for integrin localization, which is critical for placement of the distant stem cell niche and stem cell activity.

However, it is not clear whether the germline stem-cell daughters differentiate by default (because they are physically distant from the niche) or whether additional signaling is necessary to initiate the differentiation program.

Interestingly, in vivo the old progenitor cells are located more distant from the endosteal niche cells in the bone marrow than young cells, suggesting that the altered niche-HSC synapses play a role in the observed age-related changes in the stem cell homing and the mobilization (Kohler et al. 2009).

To examine whether host HO-1 has an influence on the establishment of a premetastatic niche in distant organ induced by tumor-derived soluble factors, 5– 8 we subjected WT and HO-1+/− mice to i.p. injection of CM collected from tumor cells for 10 consecutive days as reported previously.

For example, it has been shown that primary tumour cells are able to contribute to the establishment of a premetastatic niche at distant sites, which in turn, serves to attract and nurture the growth of tumour cells that have left the site of the primary malignancy (Kaplan et al, 2006).

Shed cells cross the ECM to reach vessels (intravasation) and by extravasation they colonize a distant organ in a specific niche.

Cells that would have been attacked by the immune system but escaped in distant organs may find a niche there to evolve into clinically manifest disease.

In this context, it is noteworthy that Karnoub et al reported that bone mesenchymal stem cells (BMSC) generate a 'pre-metastatic niche' at the distant organs even before metastatic cells arrive at the site (Karnoub et al, 2007).