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A series of interviews with R&D managers suggests that linkages in geographical proximity are more likely than distant linkages to generate impulses to innovation and create significant learning effects at the firm.
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Initial mapping suggested distant linkage between wdw and the Linkage Group II (= chromosome 1, Rütten et al 2004) marker reddish5 (reddish5
This notion is supported by the observation that ESBL-EC had more diverse pulsed field patterns and resistance gene profiles, consistent with more distant epidemiological linkage between isolates.
These studies have shown that the level of gene expression is highly heritable, and it can be linked to either a local locus (cis-linkage) or a distant locus (trans-linkage).
Additionally, we found that some markers assigned to the same scaffolds were mapped on different linkage groups or distant loci within a linkage group (Additional file 1: Figure S4, Additional file 2: Table S6).
For the clustering analysis shown in Figure 2, samples were clustered using R software (v2.0.1; package class v7.2.10) and the following parameters: complete linkage; distant metric = 1 – Pearson correlation (the distance measured between any two samples was calculated using the maximal number of common targets between the two samples).
These two isolates were not grouped together in this MIRU-VNTR-based tree nor in the minimum spanning tree, although they were in the first tree including the total collection (Fig. 1), linked to a distant relationship rendering their linkage more vulnerable to the composition of the strain sample used.
Conservation of synteny and linkage between distant species is a characteristic that could be integrated in positional cloning strategies.
A direct linkage of distant dCTCF binding sites by the dCTCF multimers would be consistent with the insulator bypass experiments using pairs of the appropriately oriented multimerized dCTCF binding sites [ 15].
These data reveal a strong dependence of DNA cleavage efficiency upon metal ion-mediated interactions located some 20 Å distant from the scissile phosphodiester linkages.
All of the eQTL located outside this diagonal represent trans-linkages with a linkage peaks at loci distant from the physical location of the open reading frames.
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