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In 16/27 (59%) patients, there were additional areas of GM increase distant from the primary lesion.
The tumour microenvironment is, therefore, an immune-privileged site, and tumour cells leaving this sanctuary might become susceptible to attack by immune cells in the blood (as CTCs), or after extravasation at sites distant from the primary tumour (as DTCs 17.
In addition to MSCs selectively homing to solid tumors they also actively home to sites of metastases, distant from the primary tumor[33].
A dim optical companion has been observed, which is possibly gravitationally bound, but it is more than distant from the primary.
Zeta is a triple star system, with a companion blue-white main sequence star of spectral type B8 and apparent magnitude 9.16 around 3900 AU distant from the primary, and a white main sequence star of magnitude 9.90 and spectral type A2, some 50,000 AU away, that may or may not be gravitationally bound to the other two.
Normal lung tissue localized distant from the primary tumor as well as lung tissue samples from 20 normal lungs were used as controls.
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In the PVN classification for IDC without nodal metastasis (Table 1), a score of 1 point each was given for an FF >8 mm in dimension (Hasebe et al, 2000, 2002a), lymph vessel tumour emboli with >6 apoptotic figures, lymph vessel tumour emboli >3 mm distant from the primary-invasive tumour margin, and >2 blood vessels invaded.
The converse mechanism — mesenchymal-epithelial transition (MET) — then operates at distant sites from the primary tumor to form macrometastases from isolated micrometastatic cells.
Most breast cancer deaths are caused by distant metastasis from the primary tumor site.
The metastatic cascade comprises several steps, ultimately leading to the emergence of secondary tumors at distant sites from the primary lesions [ 1].
Mesenchymal-like carcinoma cells undergo a mesenchymal-to-epithelial transition in distant sites from the primary tumour and eventually become micrometastatic.
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