Sentence examples for distant domain from inspiring English sources

Further mapping showed that βTrCP1 bound FOXO3 primarily at the C-terminal domain (a.a. 626 673) and, to a lesser extent, at an adjacent domain (a.a. 579 625) and a distant domain (a.a. 301 346) of FOXO3 (Figure 3B; Figure S5A).

It enables the generation of new design artifacts using ideas from semantically distant domains.

We speculate that such intra-protein forces may also be a critical factor in driving coordinated conformational changes between distant domains in many other systems, which are presently not fully characterized mechanistically (Cui and Karplus, 2008; Changeux and Edelstein, 2005).

For example, most of the viruses of hyperthermophilic crenarchaea have literally no genes in common with any other viruses [ 10, 11], whereas RNA viruses share with DNA viruses and plasmids that replicate via the rolling circle mechanism only extremely distant domains in their respective replication proteins.

Biological analogies can increase creativity in design by providing related, yet distant-domain stimuli, which have been reported to lead to more innovative concepts than within-domain stimuli.

Thus, we speculate that GILP and SIMPLE represent evolutionarily distant LITAF domain proteins with functions in regulating PCD.

We also report the correlations for the more distant between-domain pairs, which might be lower than within-domain correlations simply because of the greater distance.

In addition, we find that an intermediate level of recombination – formed by a combination of components from local, adjacent and distant knowledge domains – carries the highest level of technological impact of all types of inventions.

Using data on patents obtained from the CRIOS-PATSTAT database for four EU countries (Germany, UK, France and Italy), we provide empirical evidence that bridging platforms are likely to connect more effectively innovations across distant technological domains, fostering inter-sectoral technological integration and the development of original innovation.

These structures revealed a novel fold with a high degree of structural conservation of even distant GAIN domains.

This function for the ancestral PYHIN would be expected, since ASC binding is a function also conserved in more distant pyrin domain-containing proteins such as NLRP3.