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First, STD and intra-ligand trNOE spectra were used to obtain distant constraints between ligand and protein atoms.
The RMD simulation was initiated by using unambiguous NMR distant constraints on the peptide without the presence of the disulfide bond.
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Again, the speed of the movement would not increase towards the end if it were due to constraint or extrusion; for a constrained movement always diminishes in speed as the source of constraint becomes more distant, and a body moves without constraint to the place whence it was moved by constraint.
Transportation firms use it to choose the cheapest way to consolidate, coordinate and route shipments of many products from globally distributed suppliers to distant markets subject to capacity constraints.
Besides, constraints that define distant relationships from the TCP DXMS were set by bounded constraint function, which describes a linear relationship between the penalty and the distance if it is out of range.
But even in the jet age the fantasy of being marooned on a distant isle, free from both the constraints and the comforts of civilization, has remained irresistible to cartoonists.
Although both functional and structural constraints are important for distant homolog detection, the dominance of the former over the latter may be more influential for the high specificity of sequence alignment methods based on PSSMs.
We endeavoured to provide these essential elements of RCB within the constraints of time, funding, distant mentoring and the barriers at the participants' home environment.
Lack of changes in repeats between evolutionarily distant species may reflect high functional constraint, suggesting the functional importance of repeats within a given genomic region.
The performances are better in the collaborative configuration for the simultaneous management of several constraints and the manipulation of distant regions.
The availability of such service has allowed inhabitants to engage in productive activities, and to maintain contact with distant family and loved ones without the constraints of time and space.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com