Distal to the cell periphery, the lamellipodium gives way to the lamella, a relatively extended region characterized by more condensed actin structures, most prominently actin bundles contracted by myosin II motors [ 30].
Although the hypoplastic nature of the CDH lung makes assessing the reduction of Ang-1 protein difficult to visualize, immunohistochemistry demonstrated that Ang-1 expression in CDH lungs remains significantly localized to the distal airways in the periphery, reminiscent of the canalicular stage and indicative of a possible developmental delay (Fig. 7A).
The manufacturer had marked each prosthesis with 3 tantalum markers at the outer periphery and the distal tip of the implant.
The ventral axons of presumed CaP motoneurons follow a similar path, reaching their most distal destination in the ventral periphery and then loop back to the horizontal myoseptum of the embryo (Fig. 3A).
In addition, rare EdU+/NeuroD+ cells were found at the periphery of the islet and distal to the islet, along the extrapancreatic duct in control embryos.
Two weeks after surgery, VEGF-C expression was highest at the periphery of the wounds with the distal wound margin displaying significantly more staining of VEGF-C+ cells/hpf than either the middle or proximal portion (110±4 in distal portion vs. 46±8 in middle portion; p<0.05; Figures 4A, C).
The association of SYT strands with actin filaments diminished gradually toward the distal ends of stress fibers at the cell periphery, and as demonstrated by a lack of merged signal with paxillin, SYT did not extend into focal adhesions (Figure 5B).
However, if more CO2-laden gas is removed from the periphery of the lung by the distal effects of TGI as Vc is increased, end-tidal PCO2 may remain elevated or actually rise.
Hence, it is safe to assume the shape and dimension of the distal femur and proximal tibia measured along the periphery are impacted little by the thickness of the articular cartilage.
In 1843, Syme described an amputation consisting of a bone section at the distal tibia and fibula 6 mm proximal to the periphery of the ankle joint.
